Call them VA’s “super sleuths” — only the codes they crack have more to do with genetics, and the killers they hunt go by the names of “cancer” and “heart disease.” The microscopes they work with are far too heavy to carry, and the coats they wear are not khaki trench, but laboratory white.

They are the more than 3,400 VA researchers nationwide whose meticulous work, piecing together “clues,” has led to health care breakthroughs, discoveries and treatments that improve the lives of Veterans and others. And for nearly 90 years, they’ve been working cases that would have made even Sir Arthur Conan Doyle blush!

Chances are, you or someone you know, has benefitted from their work.

The list of accomplishments includes:  therapies for tuberculosis following World War II; the implantable cardiac pacemaker; computerized axial tomography (CAT) scans; functional electrical stimulation systems that allow patients to move paralyzed limbs; the nicotine patch; the first successful liver transplants; the first powered ankle-foot prosthesis; and a vaccine for shingles.

VA researchers also found that one aspirin a day reduces by half the rate of death and nonfatal heart attacks in patients with unstable angina. More recently, VA investigators tested an insulin nasal spray that shows great promise in warding off Alzheimer’s disease, and found that prazosin (a well-tested generic drug used to treat high blood pressure and prostate problems) can help improve sleep and lessen nightmares for those with post-traumatic stress disorder.

Three VA researchers received Nobel Prizes: Dr. Andrew Schally for his research on peptide hormone production in the brain; Dr. Rosalyn Yalow for her development of radioimmunoassay to detect and measure various substances in the bloodstream; and Dr. Ferid Murad for his discoveries relating to nitric oxide, a body chemical that helps maintain healthy blood vessels.

VA Research, as part of VA’s integrated health care system – with its state-of-the-art electronic health records –has come to be viewed as a model for superior bench-to-bedside research. Overseeing this activity is VA’s Office of Research and Development (ORD), which is made up of four key divisions: biomedical (basic) research; clinical studies; rehabilitation; and health services research, which studies issues such as quality and delivery of care.

If you dig into ORD’s history, the discoveries continue:  VA researchers invented a computer system that provides patients on ventilators with more accurate respirator settings, fewer medical complications, and better outcomes. You’ll also learn about a first-of-its-kind study done at VA medical centers to optimize the design of an advanced prosthetic arm, made by DEKA Research and Development through funding from the Defense Advanced Research Projects Agency. Or, you might read about a landmark cooperative study on hypertension, which demonstrated that drug treatment is effective in controlling blood pressure and reducing the incidence of major cardiovascular events.

VA’s tuberculosis studies in 1946 were among the first-ever large-scale clinical trials, and they led to the Cooperative Studies Program, which has since produced effective treatments for diseases and conditions including schizophrenia, diabetes, depression, heart disease and stroke.

The role VA Research plays in health care for Veterans and advancing medical science is remarkable and ongoing. Researchers and volunteers work on thousands of studies at VA medical centers, outpatient clinics and nursing homes.

VA Research has developed collaborative work with academic affiliates, nonprofits and other federal agencies. For example, VA and the Department of Defense (DoD) have worked together for more than 20 years through the Defense and Veterans Brain Injury Center. Recently, VA and DoD collaborated to form the Consortium to Alleviate PTSD (CAP), which will focus on the prevention, diagnosis and treatment of PTSD, and the Chronic Effects of Neurotrauma Consortium (CENC), which will study concussion or mild TBI, and possible links to neurodegenerative diseases.

How does VA Research determine its research agenda? As part of its strategic planning process, ORD seeks input from a number of key stakeholder groups, including scientific medical experts, advisory groups, Veterans, and Veterans Service Organizations.

Veterans volunteer to participate in research projects, knowing that there may not be a direct benefit to their health. They do so, in many cases, with the hope of benefiting others in the future. Still, participants have a right to change their minds at any time. For more information about participating in research, see

What are some of the studies and initiatives to watch for in the coming year? In addition to the DoD-VA consortia, here’s a snapshot of what VA researchers are doing:

  • Across the country, VA researchers have joined with VHA clinical and operational partners in 19 new Centers of Innovation, or COINs, to ensure that research has the greatest possible impact on VHA policies, health care practices and health outcomes for Veterans.
  • Through VA’s Cooperative Studies Program, researchers are also involved in the “Health ViEWS” study (Health of Vietnam Era Women’s Study), which focuses on the physical health of women who served in the Vietnam era, as well as on their current level of disability.
  • There’s also the Million Veteran Program, which seeks to study the effects that genes have on Veterans’ health, by building one of the world’s largest databases of health and genetic information.

From biomedical research in the laboratory to clinical application in a doctor’s office, VA research has an important impact on treating and preventing disease and disability. Significant findings from thousands of studies keep surfacing – findings about cholesterol, hearing aids, PTSD, angina, Alzheimer’s disease, genomic medicine, sleep apnea, diabetes – and the list goes on.

So, if you’re looking for a compelling mystery to read while chasing away these chill winter days, be sure to visit the VA Research website at, and follow on Facebook at

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Published on Feb. 14, 2014

Estimated reading time is 5.1 min.

Views to date: 132


  1. Scott Snoopy-Smith February 23, 2014 at 1:30 am

    The VA could markedly help Veterans by simply approving disability benefits that so many of us have been fighting for years; instead of wasting hundreds of millions of dollars like VA did at the end of FY13 so as to zero the budget. While new tests and technology are great simply approving disabilities for the thousands of disabled Veterans would reduce their stress and improve their quality of life.

  2. Juan February 20, 2014 at 1:57 pm

    I’m Desert Storm Disable Veteran I tried almost everything for my migraines, back pain, depression and nothing is working I have so many pain and illness that I can not able to work anymore for two years is anything out there that I can deal with all this demons????

    • Yvonne Levardi February 24, 2014 at 12:14 pm

      Juan, please get in touch with VA’s health care system … you will find information here:, call 1-877-222-VETS (8387) or you can just go to your closest VA hospital and speak to a patient advocate there. Also, consider visiting a Veterans Service Organization (American Legion, Disabled American Veterans or similar) and they can help you get started accessing benefits.

  3. Richard Whittington February 14, 2014 at 10:28 pm

    I would like to look into becoming a volunteer for possible studies

    • Rebecca February 18, 2014 at 1:29 pm

      Hi Richard,

      The VA Office of Research and Development website has a page with information about participating in VA research – you can search by your state to find studies in your area. Here’s the link:

  4. robert p wynveen February 14, 2014 at 8:56 pm

    I like the new format.

  5. francis gutowski February 14, 2014 at 5:40 pm

    I had the good fortune to be able to go to the Palo Alto VA hospital. Because of exposure to agent orange I got prostrate cancer. Thanks to Dr. Masterson the best oncologist in the world. He asked me would I be willing to try a new therapy. I was injected with female hormone and as soon is it filtered through my system it started to attack the cancer cells in my prostrate. that was in 2009 here it is 2014 and the cancer is dormant. Dr. Masterson thank you The VA hospitals sure take care of us vets

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