In this week’s edition of Chats with the Chief, VHA Chief of Staff Jon Jensen sits down with Dr. Ann McKee, chief of Neuropathology at the VA Boston Healthcare System and director of the Boston University Center for the Study of Traumatic Encephalopathy.

McKee studies the long-term effects of hits to the head on the brain.

That’s not Alzheimer’s

McKee worked in Alzheimer’s research for ten years, studying the brains of Veterans who had passed after being diagnosed with Alzheimer’s and dementia. Then she made a discovery that changed her career and our understanding of brain injuries: While dissecting the brain of a Veteran and former world champion boxer who had been diagnosed with dementia or Alzheimer’s, McKee noticed that the brain did not show any signs of either.

Instead, it showed levels of a different protein – the tau protein – that were far beyond what she had seen in most of the brains she had studied.

So, she set out to study the brains of more Veterans who had experienced repetitive hits to the head over a long period of time, as would be typical of a boxing career.

The NFL takes notice

McKee’s research was supercharged in 2008 when the National Football League asked her to look at the brain of a former NFL player. To her astonishment, she saw the same disease she had been seeing in Veterans with a long history of small head traumas.

Today, we call this disease chronic traumatic encephalopathy, or CTE.

Ongoing efforts

While the signs of CTE – such as mood changes, depression and trouble sleeping – are noticeable, it can only be diagnosed by dissecting the brain. Thus, it cannot be diagnosed in living people, but McKee is on a mission to change that.

Today, she operates a brain bank with over 1,100 brains that have been affected by traumatic brain injuries, 600 of which have been diagnosed with CTE. And she continues to collect more from family members looking to better understand their loved one’s struggle and contribute to her research.

She hopes that by better understanding the disease, we can find new ways to diagnose and treat patients while they are still alive.

She tells Jensen in the video above, “I just want all the people that are suffering out there to know my heart goes out to them. And I am really hopeful that this work will bring greater knowledge and an end of suffering.”

By VAntage Point Contributor

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Published on Oct. 6, 2021

Estimated reading time is 2.1 min.

Views to date: 386


  1. Bruce K. Troyer October 9, 2021 at 8:52 am

    I would first of all like to Thank Dr. Ann Mckee for participating in today’s talk. My hope would be that the VA doctors and military branches take to heart what you have learned. I hope your work helps today’s military individual and future individuals.
    None of this was evident 50 years ago. It’s too late to help us now. I see by other comments that I am not the only individual stock with the dilemmas of past practice.
    Please continue with these endeavors of study.

  2. James October 6, 2021 at 11:41 pm

    Need more Information. I am a 75year old Viet Nam Veteran an have my first appointment scheduled with Memory Health at my local Veteran Health Care Center in NC.

    This will be my first appointment on memory related issues. I did have several traumatic brain tromers while serving in Viet Nam in a 8 inch Howitzer Battery with The 9th inf div.

  3. Lemuel C Bray October 6, 2021 at 4:34 pm

    Neurobehavioral testing for “denial” aka anosognosia in walking talking individuals with the condition not as severe as “unilateral neglect.”

    I have a 1985 Neurobehavioral test report that indicates “energy in denial”. Essentially the definition line of anosognosia without the diagnosis ever being recorded. If recognized and individual therapy directed at the the individual recognizing the change, since a TBI, in abilities to the detriment, a great many suicides will be avoided.

    The VA refuses to make this diagnosis because it is not in the DSM-5 when the DSM-5 diagnosis should be adjustment disorder-organic- anosognosia from brain damage.

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